Leverage HIGH THROUGHPUT SCREENING for Your Functional
Assay Analysis

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Broaden your technology portfolio with FLUORESCENCE–ACTIVATED DROPLET AND CAPSULE DETECTION

TECHNICAL NOTE High-throughput screening powered by microfluidics-based droplet sorting

TECHNICAL NOTE Sorting of semi-permeable capsules using the Styx platform

APPLICATION NOTE Single cell encapsulation in picodroplets, sorting and dispensing

STYX COMPONENTS

Styx Brochure

Styx Fact Sheet

Pressure pumps

Four integrated pressure pumps ensure precise droplet or capsule reinjection, offering accurate flow control with rapid response rates — all without the need for extra components.

4 Lasers & Detectors

Four integrated lasers (405nm, 488nm, 561nm, and 638nm) and independent wide-band detectors, create a cohesive system for efficient fluorescence excitation and accurate capture. This integration allows for a diverse range of fluorophores used in functional assays.

Forcefield Generator

Facilitates particle sorting with minimal configuration, featuring two independent channels that can operate in tandem or in distinct pulsed and continuous modes, enabling versatile workflows involving combinations of merging and sorting.

Automated Stage

Securely anchors microfluidic chips during experiments and ensures accurate chip positioning for droplet detection and imaging.

Microscope Illuminator

Provides controlled, adjustable infrared illumination, enhancing visibility and contrast in the droplet selection process without interference with commonly used fluorophores.

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High-speed Camera

Equipped with dual cameras, the system records and enables real-time observation of rapid droplet selection events at up to 4000 frames per second, concurrently capturing two independent areas for comprehensive monitoring.

Integrated Microscopy

Dual-camera microscopy enables imaging and tracking of microfluidic sorting processes at multiple scales with 1080p resolution. The two imaging sites allow investigating mechanistic sorting details and particle outcomes in positive and negative outlets.

Embedded UI

Provides users with an intuitive and interactive platform to select sorting parameters for the desired droplet or capsule population across multiple platforms, without the need of software installation.

Magnetic Chip Adapter

Provides a user-friendly snap-on electrical connection to the chip, enabling droplet sorting without the need for brittle electrode pins or fickle liquid electrodes.

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Styx is a high-throughput screening platform designed to modernize the scientific research, where complex biological parameters are driving the need for advanced functional screening capabilities. It seamlessly integrates multicolor fluorescence analysis, four pressure pumps, and easy-to-use software into an elegant and compact design to bring you the most robust fluorescence-activated droplet sorting (FADS) device on the market.

Styx enables a thousand-fold increase in screening throughput compared to plate-based technologies and allows you to screen millions of functional assays in hours, versus only thousands of functional assays completed by liquid handlers in the same time frame.

Benefits

High Throughput

Sorting rates up to 1000Hz accelerate library screening.

Functional Assays

Select and sort based on the activity of your specific target.

Adaptability

Compatible with many functional assays with a fluorescence readout.

Convenience

Fully integrated with an intuitive user interface.

Versatility

4 independent lasers support multiparameter selection.

Compact Design

Compact, portable, and wireless-ready design for seamless integration.

UNLOCK THE POWER OF FADS FOR FUNCTIONAL ASSAY
SCREENING

Break Through the Functional Screening Bottleneck with Droplet Microfluidics

Unmatched throughput
Cost-efficiency
Improved sensitivity

STYX APPLICATIONS

PROTEIN ENGINEERING

Protein engineering via directed evolution is a growing field in synthetic biology that can provide new biocatalysts based on predefined industrial or biomedical needs.

Scientific Poster

Application Note

STRAIN ENGINEERING

Strain engineering involves the modification of microbial cells to optimize their genetic and metabolic pathways for specific industrial or research applications.

White Paper

ANTIBODY DISCOVERY

Antibody discovery is the process of identifying new antibodies with a high degree of specificity for a particular target. It typically involves structural computation and library screening.