High-Throughput Screening

Functional high-throughput screening enables selection of
cells or molecules based on their functional response

Talk to an expert

Functional assays offer a powerful approach for efficient discovery of cells and molecules with a target phenotype.

Droplet microfluidics is the only technology that allows to compartmentalize and screen millions of functional assays in a single day. This in turn enables screening large libraries to uncover rare hits.

WHY USE HIGH-THROUGHPUT SCREENING?

Find your one in a million

Functional Screening

Assess the functional response rather than binding affinity

Speed

Screen hundreds of samples per second

Versatility

Compatible with most assays that rely on fluorescence readout

Massive Parallelization

Screen millions of compartments simultaneously

Cost-efficiency

Millions of droplets consume only microliters of reagents

Biocompatibility

Screen and recover live cells

HIGH-THROUGHPUT SCREENING APPLICATIONS

Cell Selection

Utilise compartmentalised functional assays to screen and recover cells based on their phenotypic properties.

In Vitro Evolution

Efficiently screen and select protein variants with desired traits in a matter of days.

Synthetic Biology

Accelerate the design-build-test cycle by efficiently selecting desired variants from massive libraries.

HIGH-THROUGHPUT SCREENING WORKFLOW

A typical workflow begins with a reaction compartmentalisation step to test individual cells or molecules in a functional assay. It is then followed by a screening step during which droplets are analysed for their fluorescence and can be selectively manipulated to target desired cells or molecules.

Sample encapsulation
Functional assay
Droplet cytometry
Droplet selection

Sample encapsulation

Inject

Merge

Mix

Store

Split

BEND TIME WITH HIGH-THROUGHPUT SCREENING PLATFORM

Platform

The platform enables droplet cytometry and on-demand manipulation applications. STYX combines fluorescence analysis and droplet handling systems and is controlled with easy-to-use software making it an ideal solution for functional screening workflows.

Your spaceship styx

RESOURCES

Learn more

Technical note:

Droplet Sorting

White paper:

Functional screening

Application note:

Directed evolution

ANY QUESTIONS ABOUT HIGH-THROUGHPUT SCREENING?

Droplet Genomics is a team of scientists that develops scalable tools and technologies, opening new paths for discoveries in high-throughput biology.

We believe that efficient molecular analysis techniques are the foundation of new discoveries. Our team is committed to addressing the challenges facing single-cell and single-molecule workflows.

If you have questions, our team of scientists is ready to share their know-how about high-throughput screening. Let’s embark on a shared discovery together!