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Selection of RNA Polymerase Mutants via Directed Evolution
The production of synthetic DNA molecules, such as single-stranded DNA (ssDNA) oligonucleotides, is essential to applications in molecular biology and bioengineering, for instance, as donor DNA for CRISPR-Cas9 genome editing, as scaffolding for DNA nanotechnology,...
Using Microfluidics to Explore Cell-to-Cell Interactions
With the ability to easily separate, manipulate, tag, and sequence individual cells, droplet microfluidics technology has contributed to the rapid expansion and maturation of single-cell biological research. At the same time, the very small liquid volumes...
RNA cytometry of single-cells using semi-permeable microcapsules
The profiling of individual cells within a heterogeneous cellular population is vital to advancing research across numerous biological and biomedical fields. Unlike bulk methods, single-cell techniques can capture the full diversity of the cellular landscape...
Heterogeneous Activation of Inflammatory Response by Virus-Like Particles in Macrophages
The inflammatory response of macrophages is a principal component of innate immunity that assists in the clearing of harmful stimuli, such as pathogens and irritants, from the body. The inflammatory response may also play a role in the development of...