SEMI-PERMEABLE CAPSULES

Novel solution for high-throughput
multi-step molecular analysis
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The semi-permeable capsule (SPC) technology allows performing multi-step workflows in a high-throughput manner while maintaining reaction compartmentalization.

Compartmentalize tens of thousands of single cells into SPCs in a matter of minutes and preform every downstream reaction in a bulk-like manner on millions of SPCs in parallel.

SEMI-PERMEABLE CAPSULE TECHNOLOGY

SPC compartments have an aqueous core that is surrounded by a hydrogel shell. The shell functions like a size-selective membrane and enables an unrestricted exchange of small reaction components (e.g. enzymes, detergents, salts) while retaining large molecules, such as mRNA and genomic DNA, and cells inside the compartments. Once generated, the SPC compartments are stable under any reaction conditions thus enabling multi-step workflows.

WHY USE SEMI-PERMEABLE CAPSULES?

Redefine single-cell analysis
Multi-step Single-cell Workflows
Perform multi-step assays without losing compartmentalization
Flexibility
Work with any cell type and perform any reaction
Massive Parallelization
Process millions of SPCs in parallel
Optimal Conditions
Perform every reaction in the workflow under optimal conditions
Biocompatibility
Efficiently culture cells with easy media exchange
Mild Release
Release intact nucleic acids or live cells under mild conditions

Semi-permeable capsule applications

01
Single-Cell Transcriptomics
Perform highly sensitive transcriptomic profiling on 100s of thousands of single cells employing scalable cell barcoding approach.
02
Microbial Single-cell Sequencing
Use even the harshest lysis conditions to access bacterial genomes, barcode in downstream steps and sequence all while retaining single-cell resolution.
03
High-Throughput Targeted Sequencing
Analyze selected gene targets within 100s of thousands of single cells using long-read sequencing to enable barcoding-free analysis.

SPC WORKFLOW PRODUCTS

Easily compartmentalize your sample into SPCs at a push of a button with a compact device.

Reagent kit provides all necessary consumables for SPC generation and degradation.

Scalability
Ease of use
Robustness
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RESOURCES

Learn more
White paper:
Multiple-step workflows

ANY QUESTIONS ABOUT THE SPC TECHNOLOGY?

Droplet Genomics is a team of scientists that develops scalable tools and technologies, opening new paths for discoveries in high-throughput biology.

We believe that efficient molecular analysis techniques are the foundation of new discoveries. Our team is committed to addressing the challenges facing single-cell and single-molecule workflows.

If you have questions, our team of scientists is ready to share their know-how about SPC technology. Let’s embark on a shared discovery together!

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